With in a few minutes of downloading Rufus one can determine the software does not make a USB CD-ROM flash drive.
We confirmed this with another article we found on the web from GetUSB.info and they explained how to burn ISO to USB. What they concluded, and so did we, is that Rufus will extract the content of an ISO file and copy those files to the USB flash drive, but the Rufus software doesn’t change the configuration of the device, to that of a CD-ROM.
What started this quest was not wanting to make a bootable Windows flash drive, but rather, find a way to make a USB read-only so the data on the flash drive would not be removed or deleted.
In addition to having the USB read-only for the content, it also makes things impossible for a virus to jump onto the flash drive and spread. Given (my day job) my company doesn’t want a flash drive with our content and logo to be able to spread a virus, so the only solution we found was making sure the USB stick was read-only in the first place.
GetUSB.info article explains what Rufus does and also how to make a USB CD-ROM flash drive, the right way.